Analyzing high blood volumes for CTCs via DLA significantly improves detection and identifies pancreatic ductal adenocarcinoma patients with poor prognosis

G Fluegen,R Guglielmi,G van Dalum,A Franken, F Prokein,C Driemel,H Neubauer,D Niederacher,T Fehm,WT Knoefel,JC Fischer,NH Stoecklein

Viszeralmedizin 2021 Gemeinsame Jahrestagung Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS), Sektion Endoskopie der DGVS, Deutsche Gesellschaft für Allgemein und Viszeralchirurgie (DGAV)Zeitschrift für Gastroenterologie（2021）

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摘要

Background Circulating tumor cells (CTCs) are associated with poor survival in patients with pancreatic ductal adenocarcinoma (PDAC). Because CTC-detection rates are low in M0-PDAC (~10%), only a small fraction of high-risk patients can be identified. Here we tested whether diagnostic leukapheresis (DLA), a clinically safe method that potentially allows to screen 2.5L peripheral blood (PB), can significantly increase CTC-detection rates in PDAC.

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关键词

pancreatic ductal adenocarcinoma patients,ctcs,high blood volumes,dla,poor prognosis

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