Update on Cutibacterium acnes

Acne is one of the most common skin inflammatory diseases, representing the top three most prevalent skin conditions in the general population worldwide (Johnson and Roberts, Vital Health Stat 11 (212):i–v, 1–72, 1978; Wolkenstein et al., Arch Dermatol 139(12):1614–9, 2003; Rea et al., Br J Prev Soc Med 30(2):107–14, 1976; Bhate and Williams, Br J Dermatol 168(3):474–85, 2013). The complex physiopathology of this dermatosis involves several key players: sebaceous gland, activation of innate immunity and microbiome with a commensal bacteria Cutibacterium acnes. In this book chapter, we propose to give an overview of the most current findings about acne physiopathology and future medical challenges ahead. This chapter will focus on the commensal bacterium Cutibacterium acnes, as it has a pivotal role in acne physiopathology, its interaction with the different microorganisms constituting skin microbiota and the innate immune system. Based on the scientific literature, this book chapter will also review the innovative therapeutic options that will be developed in the future years.