Rationale and Design of a Clinical Trial to Evaluate the Safety and Efficacy of Gum Arabic in Patients with Nephrolithiasis and Renal Cyst Simultaneously

Abstract: Elderly group is one of the most heterogeneous and vulnerable groups of the population in developed countries with a greater risk of suffering from imbalances, deficiencies and nutritional problems. Diet and nutritional status have a great influence particularly on prevention or treatment of various diseases that affect these groups. Long-term accumulation of waste in the body and age-related changes in metabolism create many problems that shorten their life expectancy. Their diet and gastrointestinal function play a key role in their Urine composition. It seems that the gastrointestinal microbiome has a great influence on metabolization and absorption of the ingredients of the diet. In this study, we concluded that oral administration of Gum Arabic dissolved in orange juice could conceivably wash out renal stone and eliminate renal cysts. The oral administration of Gum Arabic reduces kidney failure and slows its progression, which might be ascribed to their antioxidant and free radical-scavenging properties. Gum Arabic could be considered as an important natural medicinal compound, actually a fascinating one because of its high therapeutic capabilities. Objective: The purpose of this work was to evaluate the efficiency of gum Arabic as a prebiotic, mixed in fresh orange juice upon long-term consumption.