Increased Sigma-1 Receptor (S1R) Availability and Its Association with Depressive and Cognitive Symptoms in Untreated Patients with Acute Early Onset Unipolar Depression (EO-UP): a (-)-f-18-fluspidine PET Study

PM Meyer, M Strauß,GA Becker,S Hesse, K Bednasch,B Ettrich,F Zientek,M Rullmann,J Luthardt, S Fischer,M Patt,H Barthel,B Wünsch,P Brust,O Sabri

Nuklearmedizin/Nuclear-Medizin（2021）

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摘要

Ziel/Aim The S1R acts as a neuromodulator and may play a pivotal role for cognitive and behavioral processes in neuropsychiatric disorders. Cognitive dysfunction is common in UP. Using S1R-specific (-)-F-18-Fluspidine PET, the aim of this study was to investigate the S1R availability and its relationship to depressive and cognitive symptoms in untreated patients with acute EO-UP.

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