Relationship Between Plasma Extracellular Vesicles (EV) and Systemic Blood Pressure in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

Background EV are spherical particles enclosed by a lipid bilayer and classified as small EV (diameter: 50-150 nm) and large EV (50-1000 nm). We have previously shown that plasma small EV regulate blood pressure (BP) in spontaneously hypertensive rats. Lifestyle-related diseases are risk factors for hypertension development . However, roles of EV on BP regulation in obese type 2 diabetic animal models have not been clarified. We aimed to clarify relationship between elevatation of BP and plasma small EV in OLETF rats.