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Characterization of the Liver Scavenger Cell Proteome in Mouse and Rat

Zeitschrift für Gastroenterologie(2021)

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摘要
Introduction The liver is characterized by a functional and metabolic organization which is established through specialized hepatocyte subpopulations. For instance, depending on their localization within the acinus, ammonia metabolising functions of these subpopulations differ strikingly. While periportal hepatocytes contribute to ammonia detoxification through the urea cycle, perivenous scavenger cells prevent ammonia spill over into the circulation by binding NH4+ ions to glutamate via glutamine synthetase (GS). Despite intense research efforts, it is still unclear whether populations of scavenger cells is homogeneous or composed by subpopulations.
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