Neurocircuit dynamics of arbitration between decision-making strategies across obsessive-compulsive and related disorders

Darsol Seok,Reza Tadayonnejad,Wan-Wa Wong,Joseph O'Neill,Jeff Cockburn,Ausaf A Bari,John P O'Doherty,Jamie D Feusner

NeuroImage: Clinical（2022）

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摘要

•Obsessive-compulsive and related disorders (OCRD) include OCD and BDD.•Neural differences in decision-making arbitration may underlie OCRD symptoms.•Resting-state effective connectivity was used to assess arbitration circuitry.•Greater left putamen inhibition via left ventrolateral prefrontal cortex in OCRD.•Stronger left putamen inhibition was correlated with less severe symptoms.

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关键词

Obsessive-compulsive disorder,Body dysmorphic disorder,Habitual decision-making,Arbitration circuit,Dynamic effective connectivity

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