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排名必读论文期刊顶会热点AI 简史溯源树小脉星探人才迁徙塔尖人才国防情报追踪开源工具智慧手语
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Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers

Roos S. G. Sablerolles,Wim J. R. Rietdijk,Abraham Goorhuis,Douwe F. Postma,Leo G. Visser,Katharina S. Schmitz,Daryl Geers,Susanne Bogers,Eva van Haren,Marion P. G. Koopmans,Virgil A. S. H. Dalm,Neeltje A. Kootstra,Anke L. W. Huckriede,Renate Akkerman,Martin Beukema,Melvin Lafeber,Debbie van Baarle,Rory D. de Vries,P. Hugo M. van der Kuy,Corine H. GeurtsvanKessel

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要
The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.
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关键词
SARS-CoV-2,Ad26,COV2,S,waning immunity
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