FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1.

Yan Wang,Kai Wang,Jiale Fu,Yu Zhang, Yufei Mao,Xu Wang,Xiang Wang,Rutong Yu,Xiuping Zhou

Neuro-oncology（2022）

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摘要

We identify a novel mechanism by which FRK orchestrates tumor-suppression effect through phosphorylating YAP and inducing its ubiquitination by Siah1. FRK-Siah1-YAP signaling axis may serve as a potential therapeutic target for GBM treatment.

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关键词

FRK,GBM,Siah1,YAP,ubiquitination

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