139P Breast cancer risk estimation (CanRisk tool) and perception in unaffected women with family history of breast cancer

Improvement of the accuracy of risk estimation is one of the most challenging goals of cancer risk assessment for women at risk of familial breast cancer (BC) without germline pathogenic variants in known susceptibility genes. Comprehensive risk prediction models such as CanRisk achieve the highest risk stratification by considering a full set of established risk factors. Our aims were: (i) to assess the difference between women´s risk perception and CanRisk-based risk prediction; and (ii) to compare CanRisk-based BC risk estimation with and without the incorporation of breast density (BD).