Shenkang injection protects against renal fibrosis by reducing perforin expression through the STING/TBK1/IRF3 signaling pathways in natural killer cells

Junfeng Hao,Xin Huang,Jibin Guan,Jingwen Feng,Dongyang Li,Shiyu Cao,Yuxuan Li,Yong Liao,Xiaotian Sun,Dajun Liu,Xiaoyu Li

Phytomedicine（2022）

引用 9|浏览16

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摘要

•NK cells activation aggravates tubulointerstitial damage.and fibrosis.•High dose SKI alleviates inflammatory renal injury and fibrosis in FA-induced RIF mice.•SKI could decrease the activation of NK cells via the STING/TBK1/IRF3 pathway.

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关键词

Shenkang injection,Renal interstitial fibrosis,Natural killer cells,Chronic kidney disease,Perforin,Interferon-γ

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