Neobavaisoflavone inhibits allergic inflammatory responses by suppressing mast cell activation

Rui Liang,Yaqin Yuan,Yakun Bai,Xinnan Liu,Jieqiong Chen, Dandan Jiang,Dehua Meng,Guangjie Chen,Bin Li,Luxian Zhou,Wenzhi Guo

International Immunopharmacology（2022）

引用 3|浏览16

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摘要

•NBIF attenuates the levels of IgE and type 2 cytokines in OVA-induced asthma.•NBIF inhibits mast cell degranulation and secretion of inflammatory mediators.•NBIF weakens NF-κB pathway and MAP kinase pathway signal transduction in mast cells.•NBIF alleviates the release of allergic mediators in passive systemic anaphylaxis.•NBIF could have potential applications in anti-allergic treatment.

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关键词

Neobavaisoflavone (NBIF),Bone marrow–derived mast cells (BMMCs),Asthma,Passive systemic anaphylaxis (PSA)

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