Gestational iron supplementation reverses depressive-like behavior in post-partum Sprague Dawley rats: Evidence from behavioral and neurohistological studies

Kennedy Kwami Edem Kukuia, Joseph Torbi,Patrick Amoateng,Kevin Kofi Adutwum-Ofosu,Awo Efua Koomson, Frimpong Appiah,Thomas Amatey Tagoe,Jeffrey Amoako Mensah,Elvis Ofori Ameyaw,Ofosua Adi-Dako,Seth Kwabena Amponsah

IBRO Neuroscience Reports（2022）

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摘要

•Iron supplementation during gestation exerts an antidepressant-like effect in postpartum Sprague-Dawley rats.•Iron supplementation during gestation attenuates neuronal loss associated with depression.•Iron-treated dams had a higher number of neurons with dendritic connections in the frontal cortex.

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AUC,DFx,Fe,Flx,FST,ID,HPA,NIH,OFT,PPD,VEH

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