Neoadjuvant afatinib with paclitaxel for triple-negative breast cancer and the molecular characteristics in responders and non-responders

Po-Han Lin,Ling-Ming Tseng,Yi-Hsuan Lee,Shou-Tung Chen,Dah-Cherng Yeh,Ming-Shen Dai,Liang-Chih Liu,Ming-Yang Wang,Chiao Lo, Stanley Chang,Kien Thiam Tan,Shu-Jen Chen,Sung-Hsin Kuo,Chiun-Sheng Huang

Journal of the Formosan Medical Association（2022）

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摘要

Adding afatinib to neoadjuvant paclitaxel generated a modest effect in TNBC. Exploratory molecular analysis suggested that activated PI3K, JAK2 pathways and mutation of HR genes were associated with therapeutic non-responsiveness, and amplification of DAXX genes was associated with responsiveness to afatinib in combination with paclitaxel.

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关键词

Triple-negative breast cancer,afatinib,Neoadjuvant,PI3K,Homologous recombination

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