Biofluid markers of blood-brain barrier disruption and neurodegeneration in Lewy body spectrum diseases: A systematic review and meta-analysis

Yuen Yan Wong,Che-Yuan Wu,Di Yu, Esther Kim, Melissa Wong, Renata Elez,Julia Zebarth,Michael Ouk, Jocelyn Tan, Jiamin Liao, Eileen Haydarian, Siming Li, Yaolu Fang,Peihao Li,Maureen Pakosh,Maria Carmela Tartaglia,Mario Masellis,Walter Swardfager

Parkinsonism & Related Disorders（2022）

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摘要

•Qalb was higher in PD and in PDD/DLB patients compared to HC.•Blood NfL concentrations were higher in PD and PDD/DLB compared to HC.•Concentrations of p-tau 181 were higher in PD patients compared to HC.•Qalb and NfL were higher in PDD than in PD without dementia.•Biofluid markers suggest the involvement of BBB breakdown in common Lewy body diseases.

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关键词

Lewy body,Dementia,Parkinson's disease,Blood-brain barrier,Blood biomarker,Neurofilament light chain

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