Polyfunctional Antigen Specific CD4+T cell Responses in Patients With HIV/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome

Maura Manion,Afroditi Boulougoura,Nuha Naqvi,Silvia Lucena Lage,Elizabeth Richards,Christopher Grivas,Elizabeth Laidlaw,Safia Kuriakose,Ana M. Ortega-Villa,Saber Tadros,Gregg Roby,Adam Rupert, France Galindo,Megan Anderson,Alice Pau,George Deepe,Virginia Sheikh,Irini Sereti

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2023）

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摘要

In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.

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histoplasmosis,HIV,AIDS,IRIS

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