Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics.

Nan Zhang,Yueying Wang,Ziliang Chen,Daiqi Liu,Gary Tse,Panagiotis Korantzopoulos,Konstantinos P Letsas,Christos A Goudis,Gregory Y H Lip,Guangping Li,Zhiwei Zhang,Tong Liu

Frontiers in nutrition（2022）

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摘要

Using summary statistics, this MR study suggests that genetically predicted circulating vitamin D concentrations, especially for a non-deficient range, were not causally associated with AF in the general population. Future studies using non-linear design and focusing on the vitamin D deficiency population are needed to further evaluate the causal effect of vitamin D concentrations on AF.

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Mendelian randomization,atrial fibrillation,causal association,single-nucleotide polymorphisms,vitamin D

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