Alterations of Cardiac Protein Kinases in Cyclic Nucleotide-Dependent Signaling Pathways in Human Ischemic Heart Failure.

Chunguang Wang,Juuso H Taskinen,Heli Segersvärd,Katariina Immonen,Riikka Kosonen,Johanna M Tolva,Mikko I Mäyränpää,Petri T Kovanen,Vesa M Olkkonen,Juha Sinisalo,Mika Laine,Ilkka Tikkanen,Päivi Lakkisto

Frontiers in cardiovascular medicine（2022）

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摘要

The deficiency in cAMP/PKA signaling pathway is strongly implicated in the pathogenesis of IHD. Natriuretic peptide CNP could be a potential therapeutic target for the modulation of cGMP/PKG signaling.

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关键词

cAMP-dependent protein kinase,cGMP-dependent protein kinase,cardiac kinome,ischemic heart disease,ischemic heart failure,natriuretic peptide,second messenger intracellular signaling

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