Imaging DNA double-strand breaks — are we there yet?
NATURE REVIEWS MOLECULAR CELL BIOLOGY（2022）
摘要
DNA double-strand breaks (DSBs) are fundamental to cell biology, from evolution to the latest gene-editing technologies. Yet, does an assay exist that truly quantitatively visualizes DSBs? Over-reliance on DSB detection by proxies can misguide interpretation of conventional assays, and more faithful DSB representatives await development.
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关键词
DNA damage and repair,Fluorescence imaging,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells,Biochemistry
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