TB-Molecular Bacterial Load Assay reveals early delayed bacterial killing in relapse patients

Nyanda Elias Ntinginya, Abishek Bakuli,Daniel Mapamba,Wilber Sabiiti,Gibson Kibiki,Lilian Tina Minja,Davis Kuchaka,Klaus Reither,Patrick Peter John Phillips,Martin Johan Boeree, Stephen H Gillespie,Michael Hoelscher,Norbert Heinrich

Clinical Infectious Diseases（2022）

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摘要

Abstract Bacterial killing in TB-patients with relapse was compared to patients achieving cure, measured by TB-molecular bacterial load assay(TB-MBLA) or MGIT time to positivity(TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.

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early delayed bacterial killing,tuberculosis

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