IMPORTANCE OF WEIGHT MANAGEMENT ON ENDOTHELIAL FUNCTION IN SPONDYLOARTHRITIS

BackgroundSubclinical atherosclerosis is not rare in spndyloarthritis (SpA) patients. Endothelial dysfunction is the first step of atherosclerosis process. Obesity is a major traditional cardiovascular risk factor.ObjectivesThe purpose of our study was to determine the association of anthropometric measures with endothelial dysfunction in non-obese SpA patients.MethodsThis was a prospective study conducted over 12 months and including 47 SpA free cardiovascular disease patients and aged less than 50 years. The following anthropometric parameters were collected for each patient: weight, height, Body Mass Index (BMI), hip and waist circumferences. Endothelial dysfunction was assessed by the ultrasound evaluation of the Flow Mediated Dilatation (FMD).ResultsThere were 14 female (28.8%) and 33 male (70.2%). The median age was 36 years (IQR; 18-50). The median disease duration was 11 years (IQR; 1-32). The median weight, height and BMI were 69 (IQR; 43-95), 170 cm (IQR; 144-193) and 24.5 kg/m2 (IQR; 16.33 - 29.41), respectively. Overweight (BMI: 25-29 kg/m2) was noted in 40% of patients. The median hip and waist circumferences were respectively 100 cm (IQR; 84-116) and 88 cm (IQR; 70-114). Median FMD was 18.18% (IQR; 12.8-23.1). We didn’t found correlation between anthropometric parameters and FMD: weight (p=0.225; r=-0.180); height (p=0.273; r=-0.163), BMI (p=0.437; r=-0.116); waist circumference (p=0.22; r=-0.182) and hip circumferences (p=0.142; r=-0.217).ConclusionOur study showed that anthropometric parameters do not influence endothelial function in non-obese and young SpA patients. This highlights the importance of weight management and maintaining a healthy weight in SpA patients.Disclosure of InterestsNone declared