AAV-based gene therapy partially rescues hearing in a DFNB93 mouse model

David Oestreicher,Vladan Rankovic, MagdalenaMaria Picher,Dirk Beutner,Tobias Moser,Tina Pangrsic

Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten MedizinLaryngo-Rhino-Otologie（2022）

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摘要

With recent advances in the field of gene therapeutics, gene therapy to target monogenetic hearing impairment promises to be a selective treatment option offering better, close to normal hearing performance, than currently used hearing aids or cochlea implants. AAV-based gene therapeutic approaches have already shown efficient restoration of hearing in mouse models, e.g. DFNA25, DFNA36 and DFNB9.

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关键词

gene therapy,dfnb93 mouse model,aav-based

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