Discovery of Novel α-Carboline Inhibitors of the Anaplastic Lymphoma Kinase.

Luca Mologni,Sébastien Tardy,Alfonso Zambon,Alexandre Orsato,William H Bisson,Monica Ceccon,Michela Viltadi, Joseph D'Attoma,Sara Pannilunghi,Vito Vece,Jerome Bertho,Peter Goekjian,Leonardo Scapozza,Carlo Gambacorti-Passerini

ACS Omega（2022）

引用 5|浏览9

暂无评分

摘要

The anaplastic lymphoma kinase (ALK) is abnormally expressed and hyperactivated in a number of tumors and represents an ideal therapeutic target. Despite excellent clinical responses to ALK inhibition, drug resistance still represents an issue and novel compounds that overcome drug-resistant mutants are needed. We designed, synthesized, and evaluated a large series of azacarbazole inhibitors. Several lead compounds endowed with submicromolar potency were identified. Compound 149in vitro149

查看译文

关键词

anaplastic lymphoma kinase”,inhibitors

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要