Abeta-induced presynaptic release of UBC9 through extracellular vesicles involves SNAP23
Neuroscience Letters(2022)
摘要
•Aβ induces the redistribution of UBC9 from presynaptic to postsynaptic terminals.•Aβ mediates presynaptic release of UBC9 by extracellular vesicles.•SNAP-23 is involved in extracellular vesicles-mediated presynaptic release of UBC9.•Phosphorylation of SNAP-23 promoted Aβ-induced presynaptic release of UBC9.•The study reveals the mechanism of extracellular vesicles-mediated presynaptic release of UBC9.
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关键词
UBC9,Alzheimer’s disease,Extracellular vesicles,SNAP23
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