Folic acid-mesoporous silicon nanoparticles enhance the anticancer activity of the p73-activating small molecule LEM2

Ana Sara Gomes,Alexandra Correia,Antti Rahikkala,Ermei Mäkilä,Madalena M Pinto,Emília Sousa,Jarno Salonen,Lucília Saraiva,Hélder A Santos

International Journal of Pharmaceutics（2022）

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摘要

•Thermally carbonized mesoporous silicon nanoparticles were conjugated with folic acid.•Nanoparticles increased LEM2 solubility, by amorphization.•Nanoparticles were stable and cytocompatible with cancer cells.•LEM2-loaded nanoparticles were uptaken and improved LEM2 cytotoxicity.

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关键词

Porous silicon,Nanoparticle,P73,Anticancer,Small molecule,Bioavailability

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