Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells

Mingkwan Greenwood,Benjamin T Gillard, Rizwan Farrukh,Alex Paterson,Ferdinand Althammer,Valery Grinevich,David Murphy,Michael P Greenwood

Molecular Metabolism（2022）

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摘要

•A multiomic investigation of transcription factor Creb3l1 in the hypothalamus.•Creb3l1 targets ER and ribosomal genes to preserve cellular proteostasis.•Identification of Creb3l1 as a major controller of the PERK arm of the UPR pathway.•Knockdown of Creb3l1 in the PVN and SON inhibits hormone synthesis and secretion.•Hypothalamic Creb3l1 expression regulates food and water intake.

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关键词

Unfolded protein response,Endoplasmic reticulum stress,Ribosome,Neuropeptide,Hypothalamus,PERK

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