Cyclic Guanidine Containing Amino Acids that Promote Glucocerebrosidase

Patrick Joseph Murphy,Zahraa S. Al-Taie,Barbara Bartholomew,Simon J. Coles,Jackie Hollinshead,Leigh F. Jones,Rolf Kraehenbuehl,Robert J. Nash, Yana B. Penkova,Graham J. Tizzard,Daniel M. Evans

SSRN Electronic Journal（2022）

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摘要

Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from L-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase.(c) 2022 Elsevier Ltd. All rights reserved.

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关键词

Cyclic guanidines, Glycosidase inhibitors, Glycosidase promoters, N -methylation

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