Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease

Shuguang Yuan,Youliang Wang,Zheng Li,Xiaojun Chen,Panai Song,Anqun Chen,Zhong Qu,Si Wen,Hong Liu,Xuejing Zhu

Archives of Biochemistry and Biophysics（2022）

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摘要

•GSDMD-mediated pyroptosis participates in tubular injury in T2DKD.•TLR4 promotes renal tubular injury by activating GSDMD-mediated pyroptosis.•GSDMD is involved in switching from apoptosis to pyroptosis in TLR4-mediated TECs injury in DKD.

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关键词

Diabetic kidney disease,Pyroptosis,Apoptosis,Toll-like receptor 4,Gasdermin D

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