At-home, sublingual ketamine telehealth is a safe and effective treatment for moderate to severe anxiety and depression: Findings from a large, prospective, open-label effectiveness trial

•Large, real-world data for an approach to delivering at-home ketamine-assisted therapy to ensure safety and increase access•Influence of side effects and degree of dissociation for this treatment were determined for subpopulations•Novel use of unsupervised machine learning to more fully characterize patient response profiles•Strong results for both depression and anxiety for a large and geographically diverse patient population