The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury

C Aulin,S Larsson,T Vogl,J Roth, A Åkesson,P Swärd,R Heinbäck,H Erlandsson Harris,A Struglics

Osteoarthritis and Cartilage（2022）

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摘要

HMGB1 and S100A8/A9 are increased as an immediate response to knee trauma. While they share many features in inflammatory and immunoregulatory mechanisms, S100A8/A9 and HMGB1 are associated to different downstream responses, which may have impact on the OA progression after acute knee injuries.

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关键词

Alarmins,HMGB1,S100A8/A9,Knee injury,Osteoarthritis

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