Hypoxia-related LncRNAs signature predicts prognosis and is associated with immune infiltration and progress of head and neck squamous cell carcinoma

Biochemistry and Biophysics Reports(2022)

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摘要
•NcRNAs regulations showed significance in hypoxia related response in HNSCC.•314 lncRNAs coexpressed with hypoxia marker genes were identified as HRLs.•An effective HRLs prognosis prediction model had been constructed and validated.•Immune cells and pathways paly roles in hypoxia related progress of HNSCC.•LINC01116 regulates HNSCC through hypoxia related immune and NF-κB/AKT signaling.
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关键词
Head and neck squamous cell carcinomas (HNSCC),Hypoxia,LncRNAs,Immune,LINC01116
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