A thermo-sensitive hydrogel composed of methylcellulose/hyaluronic acid/silk fibrin as a biomimetic extracellular matrix to simulate breast cancer malignancy

Reyhane Shokri,Miguel Fuentes-Chandía,Jafar Ai,Mehryar Habibi Roudkenar, Ali Reza Mahboubian,Mazda Rad Malekshahi,Seyed Nasser Ostad

European Polymer Journal（2022）

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摘要

•A novel thermo-sensitive hydrogel was produced using a hybrid of methylcellulose (MC), hyaluronic acid (HA), and silk fibroin (SF).•MCHASF hydrogel was used as a 3D tumor model.•MCHASF hydrogel exhibited similar stiffness to native breast tumors.•MDA-MB231 cells embedded in hydrogel exhibited characteristic of malignancy.•3D cultured cells were easily released of hydrogel at room temperature.

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关键词

3D tumor model,MDA-MB-231 cells,Thermo-sensitive hydrogel

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