Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b.

Mariavittoria D'Acierno,Roberta Resaz,Anna Iervolino,Rikke Nielsen,Donato Sardella,Sabrina Siccardi,Vincenzo Costanzo,Luciano D'Apolito,Yoko Suzumoto,Daniela Segalerba,Simonetta Astigiano,Alessandra F Perna,Giovambattista Capasso,Alessandra Eva,Francesco Trepiccione

Journal of the American Society of Nephrology : JASN（2022）

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摘要

We provide proof of concept for the efficacy of dapagliflozin in preserving kidney function in GSD1b mice. Our findings could represent the basis for repurposing this drug to treat patients with GSD1b.

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关键词

NHE-3,Napi-2,SGLT-2 inhibitors,dapagliflozin,glycogen,glycogen storage disease 1b,hexokinase-1,proximal tubule

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