Clinical Validation of Japanese Normal Myocardial Perfusion Imaging Databases Using Semi-conductor Gamma Camera (D-SPECT): Japanese Society of Nuclear Cardiology Working Group Reports.

: A working group (WG) of the Japanese Society of Nuclear Cardiology (JSNC) determined Japanese normal databases of myocardial perfusion single-photon emission computed tomography (SPECT) on semi-conductor gamma camera (D-SPECT), and the aim of this study was to validate its clinical utility. : The normal myocardial perfusion SPECT (MPS) databases of Japanese patients in the Tl stress/redistribution protocol (Tl protocol), Tc stress/rest or rest/stress protocol (Tc protocol), and rest Tc/stress Tl simultaneous acquisition dual-isotope protocol (SDI protocol) were created by JSNC WG. The WG collected clinical cases for the Tl protocol (male/female [m/f], 8/8), Tc protocol (m/f, 9/7), and SDI protocol (m/f, 10/10) from WG participating hospitals. Four WG members read those clinical cases on a 17-segment and 5-point scale (0-4). Using the most frequent values as the score for each segment, weighted κ values were calculated with the scores obtained from quantitative perfusion software (QPS). : Weighted κ values were as follows; Tl stress/female, 0.77; Tl rest/female, 0.74; Tl stress/male, 0.81; Tl rest/male, 0.68; Tc stress/female, 0.77; Tc rest/female, 0.62; Tc stress/male, 0.77; Tc rest/male, 0.75; SDI stress/female, 0.87; SDI rest/female, 0.82; SDI stress/male, 0.87; SDI rest/male, 0.85. : The diagnostic accuracy of Japanese MPS normal databases on D-SPECT were comparable with nuclear cardiology expert reading and further clinical applications are expected.