Polydopamine-heparin complex reinforced antithrombotic and antimicrobial activities of heparinized hydrogels for biomedical applications

Wenning Zhang,Yue Huang,Haozheng Wu,Yiyong Dou,Zhou Li,Hong Zhang

Composites Part A: Applied Science and Manufacturing（2022）

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摘要

•Free radical crosslinking polymerization for mass production of heparinized hydrogel.•A tightly intertwined polydopamine-heparin (PDA-HEP) complex tend to be formed.•PDA-HEP complex is proposed to maintain the bioactivity of heparin.•PDA-HEP complex endows hydrogels with antithrombotic and antibacterial properties.

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关键词

A.Polymer-matrix composites (PMCs),A. Multifunctional composites,B. Surface properties,E. Assembly

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