H2O2-Promoted Inter- and Intramolecular C-N Bond Formation: Synthesis of Quinazoline Derivatives

Hydrogen peroxide, a cheap and easily available green oxidant, can not only produce oxygen, but also produce hydroxyl radical by homogenization under the catalysis of metal. Toluene and benzyl halide can be oxidized to benzaldehyde by hydrogen peroxide and participate in the reaction with 2-aminobenzylamine. Through the construction of C-N bond, a series of quinazoline derivatives were synthesized. This reaction allows a broad range of substrates as well as good functional group compatibility.