Synthesis of 2,3-dihydroxy-3-(N-substituted carbamoyl)propylphosphonic acid derivatives as hybrid DOXP-fosmidomycin analogues

Marius K. Mutorwa,Kevin A. Lobb,Rosalyn Klein,Gregory L. Blatch,Perry T. Kaye

Journal of Molecular Structure（2022）

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摘要

•Novel enzyme substrate-enzyme inhibitor hybrids synthesized.•Enzyme-binding capacity of novel hybrids demonstrated.•Computer modelling data support receptor-site docking potential.

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关键词

DOXP-fosmidomycin hybrid analogues,Synthesis,STD-NMR,In silico docking

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