Long non-coding RNAs act as novel therapeutic targets by regulating molecular networks associated with ischemic stroke

Impaired blood supply to part of the brain results in an ischemic stroke leading to dysfunction of brain tissue. Several genetic and environmental factors can contribute to stroke. Age is one of the most important risk factors for ischemic stroke. An increased incidence of stroke related mortalities is associated with aging. The pathophysiological processes triggered by stroke, such as inflammation, apoptosis, angiogenesis, and post-stroke recovery, are well described. However, the molecular mechanisms underlying disease development remain to be studied in detail. The damage and recovery process triggered by stroke is coordinately regulated by genes involved in inflammation, immune response, and angiogenesis. The transcriptional dynamics of these key pathways determine the recovery of brain tissue from damage.