Synthesis and drug release behavior of functional montelukast imprinted inulin-based biomaterials as asthma treatment

In this study, functional montelukast (MTL) imprinted biomaterials were prepared using inulin (INL), polyvinyl alcohol (PVA), MTL, sunset yellow FCF (SY) as a light stabilizer, plasticizers, and press needle (PN). INL-based biomaterials were synthesized with a casting method followed by heat curing. MTL and biomaterials were characterized by FE-SEM, FT-IR, and 1H NMR. In addition, MTL release properties on MTL imprinted biomaterials were examined at pH 5.5 at various temperatures. Results showed that MTL release (%) of SY added biomaterials was increased by 1.97 times compared to those of MTL imprinted biomaterials without the addition of SY. This might be because SY, a light stabilizer, could inhibit the degradation of MTL by light. Results of MTL release using artificial skin verified that MTL was released sustainably for 12 h. We further confirmed that MTL release at pH 5.5 at various temperatures followed the pseudo-Fickian diffusion mechanism, whereas MTL release using artificial skin followed the non-Fickian diffusion mechanism.