The Application of Clay-Based Nanocomposite Hydrogels in Wound Healing

Recently, nanoclays have gained amount of attention as being the potential nanomaterials in the wound healing field. Due to having a high specific area, high adsorption of several therapeutic agents, good chemical inertness, and low cost, these nanomaterials are more interested in using. In this paper, we thoroughly introduced common types of nanoclays such as halloysite, kaolinite, montmorillonite, and bentonite. Interesting physical and chemical characteristics of these nanoclays are described. Further, the methods through which nanoclays are processed to form hydrogels are described. These included methods are not limited to in situ free radical polymerization, supramolecular assembly, freeze-thawing, and grafting. Finally, in this paper clay-based hydrogels and their unique properties such as antimicrobial properties and their application in wound healing are thoroughly discussed.