A common IL-4 receptor variant promotes asthma severity via a T reg cell GRB2-IL-6-Notch4 circuit.

Allergy（2022）

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摘要

These results identify an IL-4RαR576-regulated GRB2-IL-6-Notch4 circuit that promotes asthma severity by subverting lung T cell function.

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关键词

GRB2,Notch4,asthma,interleukin 4 receptor,regulatory T cells

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