Novel analytical sensing strategy using a palladium nanomaterial-based electrode for nimesulide electrochemical reduction

•A novel nanopalladium–silsesquioxane composite was designed.•Modifier material was characterized and applied for NIM sensing through reduction.•Long-term stability for the nanomaterial with the guarantee of reproducibility.•NIM voltammetric detection with low LOD and widest linear response range.•Accuracy and selectivity in the electroanalysis of environmental and clinical samples.