Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia

Zachariah Bertels,Isaac J Dripps,Pal Shah,Laura S Moye,Alycia F Tipton,Kendra Siegersma,Amynah A Pradhan

Neurobiology of Pain（2022）

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摘要

•DOR in Nav1.8 cells do not regulate anti-migraine effects of DOR agonist.•DOR in Nav1.8 cells is critical for effect of DOR agonist in peripheral OIH.•DOR in Nav1.8 cells is not necessary for effect of DOR agonist in cephalic OIH.

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Allodynia,Headache disorders,Mouse,Cortical spreading depression

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