A Case Report of Breakthrough Infections with 2 SARS-CoV-2 Variants in a Lung Transplant Patient

Luke D. Mahan,Manish R. Mohanka,John Joerns,Adrian Lawrence,Srinivas Bollineni,Vaidehi Kaza,Irina Timofte,Ricardo M. La Hoz,Jeffrey Sorelle,Lance S. Terada,Corey D. Kershaw,Fernando Torres,Amit Banga

Transplantation proceedings（2022）

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Abstract

A lung transplant (LT) patient developed 2 distinct episodes of COVID-19, confirmed by whole-genome sequencing, which was caused by the Delta, and then followed 6 weeks later, by the Omicron variant. The clinical course with Omicron was more severe, leading us to speculate that Omicron may not be any milder among LT patients. We discuss the potential mechanisms behind the Omicron not being any milder among LT patients and emphasize the need for out -comes data among these patients. Until such data become available, it may be prudent to main-tain clinical equipoise as regards the relative virulence of the newer variants among LT patients.

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