The antibacterials ciprofloxacin, trimethoprim and sulfadiazine modulate gene expression, biomarkers and metabolites associated with stress and growth in gilthead sea bream (Sparus aurata).

Ronield Fernandez,Nieves R Colás-Ruiz,Gonzalo Martínez-Rodríguez,Pablo A Lara-Martín,Juan Miguel Mancera,Chiara Trombini,Julián Blasco,Miriam Hampel

Aquatic Toxicology（2022）

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摘要

•Sparus aurata were exposed to environmental concentrations of CIP, TRIM and SULF.•Exposure to CIP and TRIM produced oxidative stress in the liver.•CIP altered the expression of genes related to the HPI and HPT axes in the brain.•Most molecular alterations were produced after CIP exposure.•Gene expression was not significantly altered after SULF and TRIM treatments.

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关键词

Antibacterial,Gene expression,Hypothalamic-pituitary axes,Oxidative stress, Sparus aurata

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