Left atrial remodeling in mitral regurgitation: A combined experimental-computational study.

Sjoerd Bouwmeester,Tim van Loon, Meike Ploeg,Thomas P Mast,Nienke J Verzaal,Lars B van Middendorp,Marc Strik,Frans A van Nieuwenhoven,Lukas R Dekker,Frits W Prinzen,Joost Lumens,Patrick Houthuizen

PloS one（2022）

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摘要

MR augmented LA strain acutely to supranormal values without significant LA dilation. However, over time, LA strain gradually decreases (pseudornormal and decompensated) with LA dilation. Histology and computer simulations indicated a correlation to a varying degree of LA eccentric remodeling and fibrosis.

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