Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles

Vladislav V Oreshko,Kseniya S Kovaleva,Ekaterina D Mordvinova,Olga I Yarovaya,Yuri V Gatilov,Dmitry N Shcherbakov,Nikolai I Bormotov,Olga A Serova,Larisa N Shishkina,Nariman F Salakhutdinov

MOLECULES（2022）

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摘要

A set of heterocyclic products was synthesized from natural (+)-camphor and semi-synthetic (-)-camphor. Then, 2-Imino-4-thiazolidinones and 2,3-dihydrothiazoles were obtained using a three-step procedure. For the synthesized compounds, their antiviral activity against the vaccinia virus and Marburg virus was studied. New promising agents active against both viruses were found among the tested compounds.

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monoterpenoids, monoterpenes, vaccinia virus, Marburg virus, heterocyclic compounds

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