Dissipation kinetics, safety evaluation, and decontamination of residues of the combo-formulation iprovalicarb 8.4% + copper oxychloride 40.6% WG in/on grapes (Vitis vinifera L.)

A field experiment was conducted to study the dissipation behavior and decontamination of iprovalicarb and copper oxychloride in grapes. After thorough validation, the analysis was carried out by employing LC-MS/MS for iprovalicarb and AAS for copper oxychloride. The dissipation pattern of residues followed a linear first-order kinetics model for both the test fungicides. The half-life values for iprovalicarb were 9.5-13.5 days, and for copper oxychloride was 24.5 days. Based on the study, a pre-harvest interval (PHI) of 17 days is proposed for the formulation. In decontamination studies, combination treatment of 0.1% sodium bicarbonate + ultrasonication and 2% lemon water + ultrasonication has shown the highest reduction of iprovalicarb (90.02% reduction) and copper oxychloride (80.14% reduction) residues, respectively. The safety evaluation data suggest that the daily exposure at all the sampling points was less than the maximum permissible intake (MPI) calculated indicating, safety to consumers. This study will be useful for promoting effective residue management and the safe use of these chemicals for controlling fungal diseases in grapes.