A microfluidic approach to fabricate sucrose decorated liposomes with increased uptake in breast cancer cells

•The overexpression of sugar receptors in cancer cells can be used as a target for nanomedicines;•Sucrose esters can be used to insert sugar moieties on the surface of nanovesicles without surface chemistry reactions;•3D printed microfluidics has been used to efficiently manufacture sucrose decorated liposomes loaded with berberine;•Sucrose decorated liposomes showed increased uptake and antiproliferative effect on breast cancer cells compared to normal liposomes.