Folate-based radiotracers for nuclear imaging and radionuclide therapy

Laurène Wagner,Bibigul Kenzhebayeva,Batoul Dhaini, Samir Boukhlef,Albert Moussaron,Serge Mordon,Céline Frochot,Charlotte Collet,Samir Acherar

Coordination Chemistry Reviews（2022）

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摘要

•Application of radiofolates in nuclear imaging of FRα-positive tumors.•Exploration of targeted radionuclide therapy using radiolotates.•Multimodal radiofolates as FRα-positive cancer theranostic tool.•Radiofolate's kidney uptake reduction using albumin-binding entity.

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%IA/g,5-Me-THF,AB,Bz,CT,Cys,CuAAC,DAV,dc,DFO,DNA,DOTA,DO3A-EA,DOTAGA,DOTATOC,DTPA,EC,ECG,EDA,EDBE,EDDA,FA,FBA,FDG,FR,Glu,Gly,HBED,His,HYNIC,IAC50,IC50,i.p.,i.v.,Kd,Log D7.4,Log P,Lys,MRI,MTT,NC,NODAGA,NOTA,OEG,PAMA,PBS,PCFT,PDT,PDX,PEG,PEG2,PET,p.i.,PMX,PSMA,RFC,RGD,ROIs,RCY,SPECT,TEPA,THF,TPPMS,TPPTS,TRT,TS

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